Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine

Akihiro Tamiya; Kazuhiro Asami; Shigeki Shimizu; Akihide Matsumura; Shun-Ichi Isa; Kyoichi Okishio; Masanori Kitaichi; Shinji Atagi; Minoru Takada; Tomoya Kawaguchi; Akihito Kubo

doi:10.2169/internalmedicine.53.2637

CASE REPORTS

Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine

Akihiro Tamiya, Kazuhiro Asami, Shigeki Shimizu, Akihide Matsumura, Shun-Ichi Isa, Kyoichi Okishio, Masanori Kitaichi, Shinji Atagi, Minoru Takada, Tomoya Kawaguchi, Akihito Kubo

Author information

Akihiro Tamiya
Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
Kazuhiro Asami
Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
Shigeki Shimizu
Department of Clinical Laboratory, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
Akihide Matsumura
Department of Surgery, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
Shun-Ichi Isa
Department of Clinical Research, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
Kyoichi Okishio
Department of Clinical Research, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
Masanori Kitaichi
Department of Clinical Laboratory, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
Shinji Atagi
Department of Clinical Research, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
Minoru Takada
Department of Internal Medicine, Koyo Hospital, Japan
Tomoya Kawaguchi
Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
Akihito Kubo
Department of Respiratory Medicine and Allergology, Aichi Medical University School of Medicine, Japan

Keywords: pleomorphic carcinoma, gemcitabine, hENT1, complete response

JOURNAL OPEN ACCESS

2014 Volume 53 Issue 22 Pages 2625-2628

DOI https://doi.org/10.2169/internalmedicine.53.2637

Details

Abstract

A 47-year-old man was referred to our department due to multiple metastases in the lungs and liver with pleural dissemination six weeks after undergoing curative surgery for lung pleomorphic carcinoma. He received two regimens of chemotherapy, both of which resulted in disease progression. Considering his good general condition, he was treated with cisplatin plus gemcitabine (GP). The metastatic lesions exhibited a complete response after six courses of GP, and the patient has remained free from recurrence for over six years. An immunohistochemical analysis revealed that the tumor was highly expressive of gemcitabine transporter human equilibrative nucleoside transporter 1, thus suggesting a high sensitivity to gemcitabine.

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