Anticonvulsant Effects of Fuzi Total Alkaloid on Pentylenetetrazole-Induced Seizure in Mice

Bingjin Li; Fang Tang; Liang Wang; Lei Liu; Jing Zhao; Yang Zhou; Yinuo Wang; Yunong Song; Yuxin Li; Ranji Cui

doi:10.1254/jphs.13057SC

Short Communication

Anticonvulsant Effects of Fuzi Total Alkaloid on Pentylenetetrazole-Induced Seizure in Mice

Bingjin Li, Fang Tang, Liang Wang, Lei Liu, Jing Zhao, Yang Zhou, Yinuo Wang, Yunong Song, Yuxin Li, Ranji Cui

Author information

Bingjin Li
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
Fang Tang
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
Liang Wang
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
Lei Liu
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
Jing Zhao
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
Yang Zhou
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
Yinuo Wang
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
Yunong Song
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
Yuxin Li
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
Ranji Cui
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
Jilin Key Laboratory of Animal Resource Conservation and Utilization, School of Life Sciences, Northeast Normal University, China

Keywords: c-Fos, seizure, pentylenetetrazole

JOURNAL FREE ACCESS

2013 Volume 123 Issue 2 Pages 195-198

DOI https://doi.org/10.1254/jphs.13057SC

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Abstract

We investigated the anticonvulsant effect of acute Fuzi total alkaloid (FTA) in seizure induced by the GABA_A-receptor antagonist pentylenetetrazole (PTZ). FTA significantly increased the seizure latency and decreased the mortality in PTZ-treated mice. Administration of PTZ increased c-Fos expression in the hippocampus, medial prefrontal cortex, and piriform cortex; and this PTZ-induced effect was inhibited by FTA in a dose-dependent manner. Furthermore, the effects of FTA on PTZ-induced seizure and c-Fos expression were reversed by the GABA_A/benzodiazepine receptor–selective antagonist flumazenil. These findings suggest that the anticonvulsant effects of FTA may be related to modulation of GABA_A–benzodiazepine receptor complex.

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