A Phytochemical in the Edible Tamogi-take Mushroom (Pleurotus cornucopiae), <small>D</small>-Mannitol, Inhibits ACE Activity and Lowers the Blood Pressure of Spontaneously Hypertensive Rats

Shin-ya HAGIWARA; Masayuki TAKAHASHI; Yanbo SHEN; Shinobu KAIHOU; Takahiro TOMIYAMA; Michio YAZAWA; Yutaka TAMAI; Yoosu SIN; Akio KAZUSAKA; Minoru TERAZAWA

doi:10.1271/bbb.69.1603

Food & Nutrition Science Note

A Phytochemical in the Edible Tamogi-take Mushroom (Pleurotus cornucopiae), D-Mannitol, Inhibits ACE Activity and Lowers the Blood Pressure of Spontaneously Hypertensive Rats

Shin-ya HAGIWARA, Masayuki TAKAHASHI, Yanbo SHEN, Shinobu KAIHOU, Takahiro TOMIYAMA, Michio YAZAWA, Yutaka TAMAI, Yoosu SIN, Akio KAZUSAKA, Minoru TERAZAWA

Author information

Shin-ya HAGIWARA
Three B Co., Inc.
Research Group for Forest Resource Science, Division of Environmental Resources, Graduate School of Agriculture, Hokkaido University
Masayuki TAKAHASHI
Bioorganic Chemistry, Division of Chemistry, Graduate School of Science, Hokkaido University
Yanbo SHEN
Research Group for Forest Resource Science, Division of Environmental Resources, Graduate School of Agriculture, Hokkaido University
Shinobu KAIHOU
Three B Co., Inc.
Takahiro TOMIYAMA
Three B Co., Inc.
Michio YAZAWA
Bioorganic Chemistry, Division of Chemistry, Graduate School of Science, Hokkaido University
Yutaka TAMAI
Research Group for Forest Resource Science, Division of Environmental Resources, Graduate School of Agriculture, Hokkaido University
Yoosu SIN
Research Group for Forest Resource Science, Division of Environmental Resources, Graduate School of Agriculture, Hokkaido University
Akio KAZUSAKA
Advanced Technology Co., Ltd.
Minoru TERAZAWA
Research Group for Forest Resource Science, Division of Environmental Resources, Graduate School of Agriculture, Hokkaido University

Keywords: angiotensin I converting enzyme (ACE) inhibitor, antihypertensive effect, D-mannitol, Tamogi-take, spontaneously hypertensive rat

JOURNAL FREE ACCESS

2005 Volume 69 Issue 8 Pages 1603-1605

DOI https://doi.org/10.1271/bbb.69.1603

Details

Abstract

D-Mannitol, one of the main phytochemicals of the edible Tamogi-take mushroom (Pleurotus cornucopiae), was found to inhibit an angiotensin I converting enzyme (ACE). The antihypertensive effect of D-mannitol and a hot water extract of Tamogi-take mushroom was demonstrated in spontaneously hypertensive rats (SHR) by oral administration.

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