Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Regular Papers
Identification of Ecl Family Genes That Extend Chronological Lifespan in Fission Yeast
Hokuto OHTSUKAYuki OGAWAHiroyuki MIZUNOSatoka MITAHirofumi AIBA
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JOURNAL FREE ACCESS

2009 Volume 73 Issue 4 Pages 885-889

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Abstract

In fission yeast, we identified two genes, named ecl2+ and ecl3+, that are paralogous to ecl1+, which extends the chronological lifespan. Both ecl2+ and ecl3+ extend the chronological lifespan when overexpressed as ecl1+. ecl2+ and ecl3+ encode 84- and 89-amino acid polypeptides respectively that are not annotated in the current database. The Ecl2 protein is localized mainly in the nucleus, as Ecl1. These results suggest that ecl1+, ecl2+, and ecl3+ have overlapping functions in the regulation of chronological lifespan.

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© 2009 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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