Effects of Glucose Abnormalities on In-Hospital Outcome After Coronary Intervention for Acute Myocardial Infarction

Masami Kosuge; Kazuo Kimura; Sunao Kojima; Tomohiro Sakamoto; Kunihiko Matsui; Masaharu Ishihara; Yujiro Asada; Chuwa Tei; Shunichi Miyazaki; Masahiro Sonoda; Kazufumi Tsuchihashi; Masakazu Yamagishi; Yoshihiko Ikeda; Mutsunori Shirai; Hisatoyo Hiraoka; Takeshi Inoue; Fumio Saito; Hisao Ogawa; on behalf of the Japanese Acute Coronary Syndrome Study (JACSS) Investigators

doi:10.1253/circj.69.375

Clinical Investigation

Effects of Glucose Abnormalities on In-Hospital Outcome After Coronary Intervention for Acute Myocardial Infarction

Masami Kosuge, Kazuo Kimura, Sunao Kojima, Tomohiro Sakamoto, Kunihiko Matsui, Masaharu Ishihara, Yujiro Asada, Chuwa Tei, Shunichi Miyazaki, Masahiro Sonoda, Kazufumi Tsuchihashi, Masakazu Yamagishi, Yoshihiko Ikeda, Mutsunori Shirai, Hisatoyo Hiraoka, Takeshi Inoue, Fumio Saito, Hisao Ogawa, on behalf of the Japanese Acute Coronary Syndrome Study (JACSS) Investigators

Author information

Masami Kosuge
Division of Cardiology, Yokohama City University Medical Center
Kazuo Kimura
Division of Cardiology, Yokohama City University Medical Center
Sunao Kojima
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Tomohiro Sakamoto
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Kunihiko Matsui
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Masaharu Ishihara
Department of Cardiology, Hiroshima City Hospital
Yujiro Asada
First Department of Pathology, Miyazaki University School of Medicine
Chuwa Tei
The First Department of Internal Medicine, Kagoshima University Faculty of Medicine
Shunichi Miyazaki
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center
Masahiro Sonoda
The Second Department of Cardiology, National Hospital Kyusyu Cardiovascular Center
Kazufumi Tsuchihashi
Second Department of Internal Medicine, Sapporo Medical University School of Medicine
Masakazu Yamagishi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center
Yoshihiko Ikeda
Department of Pathology, National Cardiovascular Center
Mutsunori Shirai
Department of Microbiology, School of Medicine, Yamaguchi University
Hisatoyo Hiraoka
The First Department of Internal Medicine, Kagoshima University Faculty of Medicine
Takeshi Inoue
Division of Cardiology, Oita National Hospital
Fumio Saito
Department of Cardiology, Nihon University Surugadai Hospital
Hisao Ogawa
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
on behalf of the Japanese Acute Coronary Syndrome Study (JACSS) Investigators
Author's Organization：
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University

Keywords: Glucose, Myocardial infarction, Reperfusion, Stent

JOURNAL FREE ACCESS

2005 Volume 69 Issue 4 Pages 375-379

DOI https://doi.org/10.1253/circj.69.375

Details

Abstract

Background The effects of glucose abnormalities on outcomes after percutaneous coronary intervention (PCI) remain unclear. We examined the association between glucose abnormalities and in-hospital outcome in patients undergoing PCI for acute myocardial infarction (AMI). Methods and Results A total of 849 patients with AMI who were admitted within 12 h after symptom onset and underwent emergency PCI were classified according to the presence or absence of admission hyperglycemia, defined as a blood glucose level on admission of >11 mmol/L and whether they had a history of diabetes mellitus: group 1 (n=504), non-diabetic patients without admission hyperglycemia; group 2 (n=111), diabetic patients without admission hyperglycemia; group 3 (n=87), non-diabetic patients with admission hyperglycemia; and group 4 (n=147), diabetic patients with admission hyperglycemia. Among groups 1, 2, 3 and 4, in-hospital mortality was 2.6, 2.7, 11.5 and 8.8%, respectively (p<0.01). Multivariate analysis showed that compared with group 1 patients, the odds ratio (95%confidence interval) for in-hospital mortality among those in groups 2, 3, and 4 were 0.80 (0.24-2.60, p=0.708), 2.29 (1.10-5.49, p=0.039), and 2.14 (1.14-4.69, p=0.048), respectively. Conclusions In-patients undergoing PCI for AMI, admission hyperglycemia, irrespective of the presence or absence of diabetes, is associated with increased in-hospital mortality, whereas diabetes without admission hyperglycemia is not. (Circ J 2005; 69: 375 - 379)

Corresponding author

Register with J-STAGE for free!