Patients After Atrial Switch Operation for Transposition of the Great Arteries Can Not Increase Stroke Volume Under Dobutamine Stress as Opposed to Patients With Congenitally Corrected Transposition

Sohrab Fratz; Alfred Hager; Raymonde Busch; Harald Kaemmerer; Markus Schwaiger; Rüdiger Lange; John Hess; Heiko C. Stern

doi:10.1253/circj.72.1130

Clinical Investigation

Patients After Atrial Switch Operation for Transposition of the Great Arteries Can Not Increase Stroke Volume Under Dobutamine Stress as Opposed to Patients With Congenitally Corrected Transposition

Sohrab Fratz, Alfred Hager, Raymonde Busch, Harald Kaemmerer, Markus Schwaiger, Rüdiger Lange, John Hess, Heiko C. Stern

Author information

Sohrab Fratz
Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Kliniken an der Technischen Universität München
Alfred Hager
Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Kliniken an der Technischen Universität München
Raymonde Busch
Department Institute for Medical Statistics and Epidemiology, Klinikum Rechts der Isar, Kliniken an der Technischen Universität München
Harald Kaemmerer
Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Kliniken an der Technischen Universität München
Markus Schwaiger
Department of Nuclear Medicine, Klinikum Rechts der Isar, Kliniken an der Technischen Universität München
Rüdiger Lange
Department of Cardiac Surgery, Deutsches Herzzentrum München, Kliniken an der Technischen Universität München
John Hess
Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Kliniken an der Technischen Universität München
Heiko C. Stern
Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Kliniken an der Technischen Universität München

Keywords: Atrial switch, Magnetic resonance imaging, Systemic right ventricle, Transposition of the great arteries

JOURNAL FREE ACCESS

2008 Volume 72 Issue 7 Pages 1130-1135

DOI https://doi.org/10.1253/circj.72.1130

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Abstract

Background Patients after atrial switch operation for transposition of the great arteries have limited exercise performance. Rigid atrial baffles may cause a relative preload reduction. Previous studies have had suboptimal control groups, which ideally should consist of patients with congenitally corrected transposition of the great arteries (ccTGA) without previous heart surgery, having a systemic right ventricle, but lacking rigid atrial baffles. Therefore the aim of this study was to test the impact of atrial baffles by comparing 12 atrial switch patients with 11 ccTGA patients. Methods and Results Systemic right ventricular stroke volume (SV), heart rate, cardiac index, and other parameters were assessed during rest and dobutamine stress magnetic resonance imaging. The most important difference between the groups was that the atrial switch patients could not increase SV during stress, whereas ccTGA patients increased it significantly. There was no difference between groups in the rise of the cardiac index. Heart rate increased significantly more in atrial switch patients than in ccTGA patients. Conclusions The results support the hypothesis that atrial baffles restrict a rise in SV under dobutamine stress in patients after atrial switch operation for transposition of the great arteries. (Circ J 2008; 72: 1130 - 1135)

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