Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Four New Cycloartane Glycosides from Aquilegia vulgaris and Their Immunosuppressive Activities in Mouse Allogeneic Mixed Lymphocyte Reaction
Makiko NishidaHitoshi YoshimitsuMasafumi OkawaToshihiro Nohara
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2003 Volume 51 Issue 6 Pages 683-687

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Abstract

Four new cycloartane glycosides, named aquilegiosides C—F, were isolated from the dried aerial parts of Aquilegia vulgaris. Their structures were determined by two dimensional (2D) NMR spectroscopic analysis and chemical evidence. Aquilegiosides C—F suppressed the proliferation of lymphocytes in mouse allogeneic mixed lymphocyte reaction with IC50, ranging from 3.7×10−5 to 2.2×10−4 M.

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© 2003 The Pharmaceutical Society of Japan
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