Differentiation and Regeneration of Adrenal Tissues: An Initial Step toward Regeneration Therapy for Steroid Insufficiency

Toshihiko YANASE; Shigeki GONDO; Taijiro OKABE; Tomoko TANAKA; Hisao SHIROHZU; Wuqiang FAN; Koichi OBA; Hidetaka MORINAGA; Masatoshi NOMURA; Kenji OHE; Hajime NAWATA

doi:10.1507/endocrj.KR-74

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Differentiation and Regeneration of Adrenal Tissues: An Initial Step toward Regeneration Therapy for Steroid Insufficiency

Toshihiko YANASE, Shigeki GONDO, Taijiro OKABE, Tomoko TANAKA, Hisao SHIROHZU, Wuqiang FAN, Koichi OBA, Hidetaka MORINAGA, Masatoshi NOMURA, Kenji OHE, Hajime NAWATA

Author information

Toshihiko YANASE
Department of Medicine and Bioregulatory Science (Third Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University
Shigeki GONDO
Department of Medicine and Bioregulatory Science (Third Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University
Taijiro OKABE
Department of Medicine and Bioregulatory Science (Third Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University
Tomoko TANAKA
Department of Medicine and Bioregulatory Science (Third Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University
Hisao SHIROHZU
Department of Medicine and Bioregulatory Science (Third Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University
Wuqiang FAN
Department of Medicine and Bioregulatory Science (Third Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University
Koichi OBA
Department of Medicine and Bioregulatory Science (Third Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University
Hidetaka MORINAGA
Department of Medicine and Bioregulatory Science (Third Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University
Masatoshi NOMURA
Department of Medicine and Bioregulatory Science (Third Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University
Kenji OHE
Department of Medicine and Bioregulatory Science (Third Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University
Hajime NAWATA
Graduate School of Medical Sciences, Kyushu University

Keywords: Bone marrow cell, Ad4BP/SF-1, Steroidogenic cell, Transplantation, Regeneration, Gene therapy

JOURNAL FREE ACCESS

2006 Volume 53 Issue 4 Pages 449-459

DOI https://doi.org/10.1507/endocrj.KR-74

View "Advance Publication" version (June 27, 2006).

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Abstract

In animal experiments, adrenal cortical tissue has been successfully regenerated through xenotransplantation of cloned adrenocortical cells, suggesting that the intraadrenal stem cells required for such tissue formation may be present in the adrenal cortex. Stable expression of Ad4BP/SF-1, a key factor for adrenal and gonadal development and steroidogenesis, has been shown to direct embryonic stem cells toward the steroidogenic lineage. However, this steroidogenic capacity was very limited since progesterone was only produced in the presence of an exogenous substrate. Bone marrow mesenchymal cells are thought to contain pluripotent progenitor cells, which differentiate into multiple lineages. We have demonstrated that adenovirus-mediated forced expression of SF-1 in long-term cultured bone marrow cells can produce steroidogenic cells with the capacity for de novo synthesis of various steroid hormones in response to ACTH. This discovery may represent the first step in autologous cell transplantation therapy for patients with steroid hormone deficiency.

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