Nonalcoholic Steatohepatitis with Improved Hepatic Fibrosis after Weight Reduction

Keita FUJIKAWA; Kazuyuki OHATA; Takuya HONDA; Seiji MIYAZOE; Tatsuki ICHIKAWA; Hiroki ISHIKAWA; Keisuke HAMASAKI; Kazuhiko NAKAO; Kan TORIYAMA; Katsumi EGUCHI

doi:10.2169/internalmedicine.43.289

Gastrointestinal Diseases

Nonalcoholic Steatohepatitis with Improved Hepatic Fibrosis after Weight Reduction

Keita FUJIKAWA, Kazuyuki OHATA, Takuya HONDA, Seiji MIYAZOE, Tatsuki ICHIKAWA, Hiroki ISHIKAWA, Keisuke HAMASAKI, Kazuhiko NAKAO, Kan TORIYAMA, Katsumi EGUCHI

Author information

Keita FUJIKAWA
First Department of Internal Medicine, Nagasaki University
Kazuyuki OHATA
First Department of Internal Medicine, Nagasaki University
Takuya HONDA
First Department of Internal Medicine, Nagasaki University
Seiji MIYAZOE
First Department of Internal Medicine, Nagasaki University
Tatsuki ICHIKAWA
First Department of Internal Medicine, Nagasaki University
Hiroki ISHIKAWA
First Department of Internal Medicine, Nagasaki University
Keisuke HAMASAKI
First Department of Internal Medicine, Nagasaki University
Kazuhiko NAKAO
Health Research Center, Nagasaki University
Kan TORIYAMA
Department of Pathology, Institute of Tropical Medicine, Nagasaki University
Katsumi EGUCHI
First Department of Internal Medicine, Nagasaki University

Keywords: nonalcoholic steatohepatitis, weight reduction, hepatic fibrosis

JOURNAL OPEN ACCESS

2004 Volume 43 Issue 4 Pages 289-294

DOI https://doi.org/10.2169/internalmedicine.43.289

Details

Abstract

A 65-year-old woman was admitted to our hospital for an investigation of liver dysfunction. She had mild obesity with hyperlipidemia, but no history of alcohol abuse. Other known causes of liver dysfunction, such as viruses, autoimmunity and drug effects, were excluded. The liver histology was consistent with nonalcoholic steatohepatitis (NASH). After diagnosis of NASH, the patient started diet and exercise therapy and, in parallel with weight reduction, her liver function improved. One year after the therapy, a liver biopsy showed that steatosis, necroinflammation and even fibrosis were improved. Hence, here we report a case of NASH in which weight reduction was effective in improving both biochemical and histological findings.

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