Successful Treatment of Hypersensitivity Pneumonitis Caused by Grifola frondosa (Maitake) Mushroom Using a HFA-BDP Extra-fine Aerosol

Hiroshi TANAKA; Kazunori TSUNEMATSU; Naohito NAKAMURA; Kazuhiko SUZUKI; Nobuyuki TANAKA; Isao TAKEYA; Toyohiro SAIKAI; Shosaku ABE

doi:10.2169/internalmedicine.43.737

Respiratory Diseases

Successful Treatment of Hypersensitivity Pneumonitis Caused by Grifola frondosa (Maitake) Mushroom Using a HFA-BDP Extra-fine Aerosol

Hiroshi TANAKA, Kazunori TSUNEMATSU, Naohito NAKAMURA, Kazuhiko SUZUKI, Nobuyuki TANAKA, Isao TAKEYA, Toyohiro SAIKAI, Shosaku ABE

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Keywords: hypersensitivity pneumonitis, mushroom spore, inhaled corticosteroid, hydrofluoroalkane, beclomethasone dipropinate

JOURNAL OPEN ACCESS

2004 Volume 43 Issue 8 Pages 737-740

DOI https://doi.org/10.2169/internalmedicine.43.737

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Abstract

We successfully treated a patient with occupational hypersensitivity pneumonitis (HP) caused by Grifola frondosa (Maitake) mushroom spore with an extra-fine aerosol corticosteroid; beclomethasone dipropionate (BDP) dissolved in hydrofluoroalkane-134a (HFA). A 49-year-old woman developed respiratory symptoms 3 months after beginning work on a mushroom farm. She was diagnosed as HP based on radiological and serological findings. Oral prednisolone therapy improved her HP and she returned to the same farm. Her HP relapsed after 5 months, and daily 400 μg of HFA-BDP was administered with gradual improvement. An extra-fine particle inhaled corticosteroid might reach appropriate alveoli to be effective therapy for mild HP.

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