CASE REPORTS
Cyclophosphamide-induced Cardiomyopathy in a Patient with Seminoma and a History of Mediastinal Irradiation
2005 Volume 44 Issue 2 Pages 120-123
Details
2005 Volume 44 Issue 2 Pages 120-123
A 17-year-old man with mediastinal seminoma was treated with chemotherapy and mediastinal irradiation therapy. Then he received high-dose chemotherapy containing cyclophosphamide (CY) followed by autologous peripheral blood stem cell transplantation. He suffered from CY-induced cardiomyopathy beginning six days after the administration of high-dose CY. The predictable factors associated with the onset of CY-induced cardiomyopathy are not precisely known. It is suggested that the history of mediastinal irradiation was responsible for the onset of cardiomyopathy.
