Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Virus Associated Hemophagocytic Syndrome Accompanied by Acute Respiratory Failure Caused by Influenza A (H3N2)
Masaru Ando, Eishi Miyazaki, Shigeo Hiroshige, Yoshinori Ashihara, Toshiyuki Okubo, Mami Ueo, Tetsujiro Fukami, Katsunori Sugisaki, Tomiyasu Tsuda, Kazunari Ohishi, Shigenori Yoshitake, Takayuki Noguchi, Toshihide Kumamoto
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Keywords: virus-associated hemophagocytic syndrome, acute respiratory failure, influenza
JOURNAL OPEN ACCESS

2006 Volume 45 Issue 20 Pages 1183-1186

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Abstract

A 40-year-old Japanese woman was admitted to Oita University Hospital with progressive dyspnea, consciousness disturbance and severe cytopenias. Her chest roentgenogram showed diffuse bilateral infiltrates. She was therefore forced to receive mechanical ventilation. Bone marrow aspiration disclosed numerous hemophagocytic histiocytes, thus suggesting her condition to be hemophagocytic syndrome. In addition, she also developed myocarditis and renal failure. Pulsed methylprednisolone, gamma-globulin, granulocyte colony-stimulating factor and sivelestat sodium hydrate were administrated, and thereafter the patient recovered from cytopenia and organ failure. Afterwards, influenza A H3N2 was detected from bronchial extracts. We should recognize that an influenza A virus infection can induce hemophagocytic syndrome and acute respiratory failure as the initial manifestations of multiple organ failure.

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© 2006 by The Japanese Society of Internal Medicine
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