Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Improvement of Cardiac Diastolic Function and Prognosis After Autologous Peripheral Blood Stem Cell Transplantation in AL Cardiac Amyloidosis
Shusuke YagiMasashi AkaikeShuji OzakiChikako MoriyaKyoko TakeuchiTomoko HaraMitsunori FujimuraYuka SumitomoTakashi IwaseYasumasa IkedaKen-ichi AiharaTakehiko KimuraTakeshi NishiuchiMasahiro AbeToshio Matsumoto
Author information
JOURNAL OPEN ACCESS

2007 Volume 46 Issue 20 Pages 1705-1710

Details
Abstract

AL amyloidosis is a disease in which immunoglobulin L chain is deposited in multiple organs, and the prognosis of cardiac amyloidosis is extremely poor. Although several treatments based on that for multiple myeloma, have been performed, there is no clear evidence that cardiac function is improved. We report a case of AL cardiac amyloidosis with moderate cardiac dysfunction for which we performed autologous peripheral blood stem cell transplantation (auto-PBSCT) in combination with high-dose melphalan therapy. This treatment resulted in significant improvement in cardiac function and good prognosis for about 3.5 years after the diagnosis. Therefore, auto-PBSCT is a possible option as up-front therapy for AL cardiac amyloidosis.

Content from these authors
© 2007 by The Japanese Society of Internal Medicine
Previous article Next article
feedback
Top