Gastrointestinal Hemorrhage as the First Manifestation of Metastatic Extragonadal Choriocarcinoma

Tomoyoshi Shibuya; Taro Osada; Tomohiro Kodani; Mariko Hojo; Hiroaki Saito; Hiroya Ueyama; Junko Kato; Akihito Nagahara; Michiro Otaka; Tatsuo Ogihara; Keiji Nagao; Makoto Fujime; Sumio Watanabe

doi:10.2169/internalmedicine.48.1867

CASE REPORTS

Gastrointestinal Hemorrhage as the First Manifestation of Metastatic Extragonadal Choriocarcinoma

Tomoyoshi Shibuya, Taro Osada, Tomohiro Kodani, Mariko Hojo, Hiroaki Saito, Hiroya Ueyama, Junko Kato, Akihito Nagahara, Michiro Otaka, Tatsuo Ogihara, Keiji Nagao, Makoto Fujime, Sumio Watanabe

Author information

Tomoyoshi Shibuya
Department of Gastroenterology, Juntendo University School of Medicine
Taro Osada
Department of Gastroenterology, Juntendo University School of Medicine
Tomohiro Kodani
Department of Gastroenterology, Juntendo University School of Medicine
Mariko Hojo
Department of Gastroenterology, Juntendo University School of Medicine
Hiroaki Saito
Department of Gastroenterology, Juntendo University School of Medicine
Hiroya Ueyama
Department of Gastroenterology, Juntendo University School of Medicine
Junko Kato
Department of Gastroenterology, Juntendo University School of Medicine
Akihito Nagahara
Department of Gastroenterology, Juntendo University School of Medicine
Michiro Otaka
Department of Gastroenterology, Juntendo University School of Medicine
Tatsuo Ogihara
Department of Gastroenterology, Juntendo University School of Medicine
Keiji Nagao
Department of Urology, Juntendo University School of Medicine
Makoto Fujime
Department of Urology, Juntendo University School of Medicine
Sumio Watanabe
Department of Gastroenterology, Juntendo University School of Medicine

Keywords: choriocarcinoma, gastric metastasis, endoscopy

JOURNAL OPEN ACCESS

2009 Volume 48 Issue 7 Pages 551-554

DOI https://doi.org/10.2169/internalmedicine.48.1867

Details

Abstract

Although germ cell tumors are the most common malignancy in young men, extragonadal germ cell tumors are rare. Gastric metastasis presenting initially as upper gastrointestinal hemorrhage is also exceedingly rare. A 27-year-old man presented at our hospital with tarry stool. Gastric fiberscopy images revealed a bleeding gastric polypoid lesion in the anterior wall of the gastric body, from which a biopsy specimen was obtained. Histopathological analysis of the biopsy showed syncytiotrophoblast-like cells with multiple, large nuclei, consistent with choriocarcinoma. Based on these results, our diagnosis was extragonadal retroperitoneal germ cell tumor with gastric metastasis.

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