Primitive Neuroectodermal Tumor as a Differential Diagnosis of CD56-Positive Tumors in Adults

Tadanobu Nagaya; Naoki Tanaka; Atsushi Kamijo; Satoru Joshita; Koh Nakazawa; Hideharu Miyabayashi; Suguru Yoneda; Tetsuya Ito; Michiharu Komatsu; Eiji Tanaka; Kiyoshi Kitano

doi:10.2169/internalmedicine.48.1980

CASE REPORTS

Primitive Neuroectodermal Tumor as a Differential Diagnosis of CD56-Positive Tumors in Adults

Tadanobu Nagaya, Naoki Tanaka, Atsushi Kamijo, Satoru Joshita, Koh Nakazawa, Hideharu Miyabayashi, Suguru Yoneda, Tetsuya Ito, Michiharu Komatsu, Eiji Tanaka, Kiyoshi Kitano

Author information

Tadanobu Nagaya
Department of Internal Medicine, Matsumoto Medical Center
Department of Gastroenterology, Shinshu University School of Medicine
Naoki Tanaka
Department of Gastroenterology, Shinshu University School of Medicine
Department of Metabolic Regulation, Shinshu University Graduate School of Medicine
Atsushi Kamijo
Department of Internal Medicine, Matsumoto Medical Center
Department of Gastroenterology, Shinshu University School of Medicine
Satoru Joshita
Department of Internal Medicine, Matsumoto Medical Center
Department of Gastroenterology, Shinshu University School of Medicine
Koh Nakazawa
Department of Laboratory Medicine, Matsumoto Medical Center
Hideharu Miyabayashi
Department of Internal Medicine, Matsumoto Medical Center
Suguru Yoneda
Department of Gastroenterology, Shinshu University School of Medicine
Tetsuya Ito
Department of Gastroenterology, Shinshu University School of Medicine
Michiharu Komatsu
Department of Gastroenterology, Shinshu University School of Medicine
Eiji Tanaka
Department of Gastroenterology, Shinshu University School of Medicine
Kiyoshi Kitano
Department of Internal Medicine, Matsumoto Medical Center

Keywords: primitive neuroectodermal tumor, CD56, CD99, ICE-CAV therapy

JOURNAL OPEN ACCESS

2009 Volume 48 Issue 15 Pages 1267-1272

DOI https://doi.org/10.2169/internalmedicine.48.1980

Details

Abstract

A 33-year-old Japanese man was referred to our hospital after a huge intrapelvic tumor with bilateral hydronephrosis was found following persistent lumbago. Natural killer/T-cell lymphoma was suspected due to positive immunostaining for CD56, but CHOP therapy was ineffective. Re-evaluation of the tumor cells showed that they were positive for CD99, neuron-specific enolase, and synaptophysin and had a t(11 ; 22) (q24 ; q12) translocation, leading to the revised diagnosis of primitive neuroectodermal tumor (PNET). Systemic chemotherapies and radiation therapy were added to surgical resection, and no recurrence has been detected for 3 years. Taken together, PNET may be considered in adult patients with CD56-positive tumors.

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