Acute Lung Injury with Alveolar Hemorrhage Due to a Novel Swine-Origin Influenza A (H1N1) Virus

Toshiki Yokoyama; Kenji Tsushima; Atsuhito Ushiki; Nobumitsu Kobayashi; Kazuhisa Urushihata; Tomonobu Koizumi; Keishi Kubo

doi:10.2169/internalmedicine.49.3022

CASE REPORTS

Acute Lung Injury with Alveolar Hemorrhage Due to a Novel Swine-Origin Influenza A (H1N1) Virus

Toshiki Yokoyama, Kenji Tsushima, Atsuhito Ushiki, Nobumitsu Kobayashi, Kazuhisa Urushihata, Tomonobu Koizumi, Keishi Kubo

Author information

Keywords: influenza, H1N1, alveolar hemorrhage, acute lung injury

JOURNAL OPEN ACCESS

2010 Volume 49 Issue 5 Pages 427-430

DOI https://doi.org/10.2169/internalmedicine.49.3022

Details

Abstract

A 40-year-old woman with no major medical illness except for morbid obesity (BMI 40.7) was admitted to our hospital because of bilateral pneumonia due to a novel swine-origin influenza A (H1N1) virus (S-OIV). Non-invasive ventilation was introduced because of the hypoxemia. The description of bronchoalveolar lavage fluid findings showed an alveolar hemorrhage and neutrophilic inflammation. No evidence of bacterial infection was found. She was treated with oseltamivir and sivelestat sodium, neutrophil elastase inhibitor and thereafter was successfully discharged from the hospital. This case is the first report of a patient with acute lung injury with an alveolar hemorrhage caused by the S-OIV.

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