Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Good's Syndrome-Associated Pure Red Cell Aplasia with Myelodysplastic Syndrome
Hideaki NittaYuka HaradaYoshiko OkikawaMasayoshi FujiiKoji ArihiroAkiro KimuraHironori Harada
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JOURNAL OPEN ACCESS

2011 Volume 50 Issue 18 Pages 2011-2014

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Abstract

We report a case of Good's syndrome-associated pure red cell aplasia (PRCA) with myelodysplastic syndrome (MDS). In this case, effector memory T (TEM) cells were expanded in the bone marrow. It remains uncertain whether the development of MDS was caused by the basic marrow defects or radiation therapy. However, since CD8+ perforin+ TEM cells expanded in the bone marrow, as was previously described for 3 of our patients with thymoma-associated PRCA, it is highly possible that the pathogenic mechanism of PRCA that is accompanied by thymoma is related to the expanded CD8+ perforin+ TEM cells in this MDS-complicated case.

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© 2011 by The Japanese Society of Internal Medicine
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