Efficacy of Oral Magnesium Administration on Decreased Exercise Tolerance in a State of Chronic Sleep Deprivation

Kazuhiko Tanabe; Akiko Yamamoto; Noriyuki Suzuki; Naohiko Osada; Yasuhiro Yokoyama; Hisanori Samejima; Atsushi Seki; Misa Oya; Taizo Murabayashi; Masaru Nakayama; Masanobu Yamamoto; Kazuto Omiya; Haruki Itoh; Masahiro Murayama

doi:10.1253/jcj.62.341

Clinical Study

Efficacy of Oral Magnesium Administration on Decreased Exercise Tolerance in a State of Chronic Sleep Deprivation

Kazuhiko Tanabe, Akiko Yamamoto, Noriyuki Suzuki, Naohiko Osada, Yasuhiro Yokoyama, Hisanori Samejima, Atsushi Seki, Misa Oya, Taizo Murabayashi, Masaru Nakayama, Masanobu Yamamoto, Kazuto Omiya, Haruki Itoh, Masahiro Murayama

Author information

Kazuhiko Tanabe
Second Department of Internal Medicine, st Marianna University School of Medicine
Akiko Yamamoto
Second Department of Internal Medicine, st Marianna University School of Medicine
Noriyuki Suzuki
Second Department of Internal Medicine, st Marianna University School of Medicine
Naohiko Osada
Second Department of Internal Medicine, st Marianna University School of Medicine
Yasuhiro Yokoyama
Second Department of Internal Medicine, st Marianna University School of Medicine
Hisanori Samejima
Second Department of Internal Medicine, st Marianna University School of Medicine
Atsushi Seki
Second Department of Internal Medicine, st Marianna University School of Medicine
Misa Oya
Second Department of Internal Medicine, st Marianna University School of Medicine
Taizo Murabayashi
Second Department of Internal Medicine, st Marianna University School of Medicine
Masaru Nakayama
Second Department of Internal Medicine, st Marianna University School of Medicine
Masanobu Yamamoto
Second Department of Internal Medicine, st Marianna University School of Medicine
Kazuto Omiya
Second Department of Internal Medicine, st Marianna University School of Medicine
Haruki Itoh
Second Department of Internal Medicine, st Marianna University School of Medicine
Masahiro Murayama
Second Department of Internal Medicine, st Marianna University School of Medicine

Keywords: Erythrocyte magnesium, Exercise tolerance, Magnesium administration, Norepinephrine, Sleep deprivation

JOURNAL FREE ACCESS

1998 Volume 62 Issue 5 Pages 341-346

DOI https://doi.org/10.1253/jcj.62.341

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Abstract

We have previously reported that chronic sleep deprivation causes a deficiency of intracellular magnesium (Mg) and decreased exercise tolerance. The aim of this study was to clarify whether oral administration of Mg could be effective in restoring the exercise tolerance that is decreased by chronic sleep deprivation. A bicycle ergometer cardiopulmonary exercise test was performed by 16 healthy volunteers (mean age 21.9 years). They were divided into 2 groups: 8 received doses of 100 mg of Mg orally per day for 1 month (Mg group) and the remaining 8 received no Mg and served as the control group. The study conditions were designed as follows: (1) the usual state (good sleep); and (2) the sleep-deprived state (sleeping time up to 60% Iess than the usual state for 1 month). The ratio of intracellular Mg content of the sleep-deprived state to the usual sleep state was significantly higher in the Mg group (p <0.05) than the untreated control group. There was no difference between the sleep-deprived state and the usual state with regard to anaerobic threshold and peak oxygen uptake in the Mg group, whereas both of these decreased in the sleep-deprived state in the control group. These results indicate that decreased exercise tolerance observed in the sleep-deprived state could be improved by oral Mg administration. (Jpn Circ J 1998; 62: 341-346)

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