Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice

Akira Nakajima; Tohru Yamakuni; Mitsuya Haraguchi; Naoki Omae; Si-Young Song; Chieko Kato; Osamu Nakagawasai; Takeshi Tadano; Akihito Yokosuka; Yoshihiro Mimaki; Yutaka Sashida; Yasushi Ohizumi

doi:10.1254/jphs.SC0070155

Short Communication

Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice

Akira Nakajima, Tohru Yamakuni, Mitsuya Haraguchi, Naoki Omae, Si-Young Song, Chieko Kato, Osamu Nakagawasai, Takeshi Tadano, Akihito Yokosuka, Yoshihiro Mimaki, Yutaka Sashida, Yasushi Ohizumi

Author information

Akira Nakajima
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
Tohru Yamakuni
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
Mitsuya Haraguchi
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
Naoki Omae
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
Si-Young Song
Institute of Neuroscience, Tokushima Bunri University at Kagawa, Japan
Chieko Kato
Institute of Neuroscience, Tokushima Bunri University at Kagawa, Japan
Osamu Nakagawasai
Department of Pharmacology, Tohoku Pharmaceutical University, Japan
Takeshi Tadano
Department of Pharmacology, Tohoku Pharmaceutical University, Japan
Akihito Yokosuka
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
Yoshihiro Mimaki
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
Yutaka Sashida
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
Yasushi Ohizumi
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
Yokohama College of Pharmacy, Japan
Research Center of Supercritical Fluid Technology, Graduate School of Engineering, Tohoku University, Japan

Keywords: Alzheimer’s disease, cholinergic neuron, nobiletin

JOURNAL FREE ACCESS

2007 Volume 105 Issue 1 Pages 122-126

DOI https://doi.org/10.1254/jphs.SC0070155

Details

Abstract

We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer’s disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice.

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