PAPULACANDINS, A NEW FAMILY OF ANTIBIOTICS WITH ANTIFUNGAL ACTIVITY I. FERMENTATION, ISOLATION, CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF PAPULACANDINS A, B, C, D AND E

P. TRAXLER; J. GRUNER; J. A. L. AUDEN

doi:10.7164/antibiotics.30.289

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

PAPULACANDINS, A NEW FAMILY OF ANTIBIOTICS WITH ANTIFUNGAL ACTIVITY

I. FERMENTATION, ISOLATION, CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF PAPULACANDINS A, B, C, D AND E

P. TRAXLER, J. GRUNER, J. A. L. AUDEN

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JOURNAL FREE ACCESS

1977 Volume 30 Issue 4 Pages 289-296

DOI https://doi.org/10.7164/antibiotics.30.289

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Abstract

Papulacandin, a new antibiotic complex, active against Candida albicans and several other yeasts, was isolated from a strain of Papularia sphaerosperma. The fermentation, isolation, physico-chemical properties and biological activity of the five structurally related papulacandins A, B, C, D and E are reported. Papulacandin B, the main component, was assigned the formula of C₄₇H₆₄O₁₇.

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