STUDIES ON ACULEACIN I ISOLATION AND CHARACTERIZATION OF ACULEACIN A

KIMIO MIZUNO; AKIRA YAGI; SHUZO SATOI; MASAKI TAKADA; MITSUO HAYASHI; KATSUMI ASANO; TETSUO MATSUDA

doi:10.7164/antibiotics.30.297

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

STUDIES ON ACULEACIN

I ISOLATION AND CHARACTERIZATION OF ACULEACIN A

KIMIO MIZUNO, AKIRA YAGI, SHUZO SATOI, MASAKI TAKADA, MITSUO HAYASHI, KATSUMI ASANO, TETSUO MATSUDA

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JOURNAL FREE ACCESS

1977 Volume 30 Issue 4 Pages 297-302

DOI https://doi.org/10.7164/antibiotics.30.297

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Abstract

Aculeacin A, a new antifungal antibiotic was isolated from the mycelial cake of Aspergillus aculeatus M-4214. The antibiotic is a white amorphous powder soluble in lower alcohols and hardly soluble in other organic solvents or water. Aculeacin A gave palmitic acid and five ninhydrin-positive products including threonine, hydroxyproline upon acid hydrolysis. The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity. Aculeacin A has relatively low toxicity in mice.

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