PLASMID-MEDIATED PRISTINAMYCIN RESISTANCE PAC IIA: A NEW ENZYME WHICH MODIFIES PRISTINAMYCIN IIA

FRANÇOIS LE GOFFIC; MARIE-LOUISE CAPMAU; DIDIER BONNET; CLAUDE CERCEAU; CLAUDE SOUSSY; ALAIN DUBLANCHET; J. DUVAL

doi:10.7164/antibiotics.30.665

PLASMID-MEDIATED PRISTINAMYCIN RESISTANCE

PAC IIA: A NEW ENZYME WHICH MODIFIES PRISTINAMYCIN IIA

FRANÇOIS LE GOFFIC, MARIE-LOUISE CAPMAU, DIDIER BONNET, CLAUDE CERCEAU, CLAUDE SOUSSY, ALAIN DUBLANCHET, J. DUVAL

Author information

JOURNAL FREE ACCESS

1977 Volume 30 Issue 8 Pages 665-669

DOI https://doi.org/10.7164/antibiotics.30.665

Details

Abstract

A wild strain of Staphylococcus aureus which inactivates a wide variety of antibiotics has been found to inactivate pristinamycin IIA, an antistaphylococcal antibiotic. This phenomenon has been demonstrated to be plasmid mediated. The plasmid directs the biosynthesis of an acetyltransferase which is able to O-acetylate the drug. We propose to call the new enzyme PAC (IIA): Pristinamycin acetyltransferase.

Corresponding author

Register with J-STAGE for free!