The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
THE SYNTHESES AND BIOLOGICAL PROPERTIES OF 1-N-(S-4-AMINO- 2-HYDROXYBUTYRYL)-GENTAMICIN B AND 1-N-(S-3-AMINO- 2-HYDROXYPROPIONYL)-GENTAMICIN B
T. L. NAGABHUSHANA. B. COOPERH. TSAIP. J. L. DANIELSG. H. MILLER
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1978 Volume 31 Issue 7 Pages 681-687

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Abstract

The syntheses of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B, designated Sch 20287 and Sch 21420, respectively, by procedures similar to those developed by KAWAGUCHI and co-workers for the transformation of kanamycin A to amikacin are described. The in vitro microbiological properties of Sch 20287 and Sch 21420 are compared with amikacin, gentamicin and tobramycin.

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© Japan Antibiotics Research Association
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