STUDIES ON PEPTIDE ANTIBIOTICS, LEUCINOSTATINS I. SEPARATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES OF LEUCINOSTATINS A AND B

KAZUTAKA FUKUSHIMA; TADASHI ARAI; YUJI MORI; MAKOTO TSUBOI; MAKOTO SUZUKI

doi:10.7164/antibiotics.36.1606

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

STUDIES ON PEPTIDE ANTIBIOTICS, LEUCINOSTATINS

I. SEPARATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES OF LEUCINOSTATINS A AND B

KAZUTAKA FUKUSHIMA, TADASHI ARAI, YUJI MORI, MAKOTO TSUBOI, MAKOTO SUZUKI

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JOURNAL FREE ACCESS

1983 Volume 36 Issue 12 Pages 1606-1612

DOI https://doi.org/10.7164/antibiotics.36.1606

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Abstract

Leucinostatin, a peptide antibiotic, was separated by silica gel and alumina column chromatography into two related components designated as leucinostatin A hydrochloride (C₆₁H₁₁₁N₁₁O₁₃•HCl) and leucinostatin B hydrochloride (C₆₁H₁₀₉N₁₁O₁₃•HCl). Physico-chemical as well as biological properties of the two separated components were analyzed. These properties pointed to closely resembling chemical structures.

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