The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SPECIFIC INHIBITION OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE BY KONINGIC ACID (HEPTELIDIC ACID)
AKIRA ENDO, KENJI HASUM, KENJI HASUMI, KAORU SAKAI, TOMOMI KANBE
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JOURNAL FREE ACCESS

1985 Volume 38 Issue 7 Pages 920-925

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Abstract

A sesquiterpene named koningic acid has been isolated from a strain of Trichoderma koningii as a potent inhibitor of ATP generation in the glycolytic pathway. From experiments with both cultured mouse carcinoma FM3A cells and isolated enzymes, it was shown that koningic acid is a specific inhibitor of glyceraldehyde 3-phosphate dehydrogenase that catalyzes the conversion of glyceraldehyde 3-phosphate to 3-phosphoglycerate.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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