NEW PEPTIDE ANTIBIOTICS LI-F03, F04, F05, F07, AND F08, PRODUCED BY BACILLUS POLYMYXA I. ISOLATION AND CHARACTERIZATION

KEIJI KURUSU; KENKICHI OHBA; TADASHI ARAI; KAZUTAKA FUKUSHIMA

doi:10.7164/antibiotics.40.1506

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

NEW PEPTIDE ANTIBIOTICS LI-F03, F04, F05, F07, AND F08, PRODUCED BY BACILLUS POLYMYXA

I. ISOLATION AND CHARACTERIZATION

KEIJI KURUSU, KENKICHI OHBA, TADASHI ARAI, KAZUTAKA FUKUSHIMA

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JOURNAL FREE ACCESS

1987 Volume 40 Issue 11 Pages 1506-1514

DOI https://doi.org/10.7164/antibiotics.40.1506

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Abstract

A strain of Bacillus polymyxa produced a new peptide antibiotic complex, named LI-F, composed of more than ten components. The components, antibiotics LI-F03, F04, F05, F07, and F08 were isolated from the complex by reversed phase HPLC. They are active against fungi, yeasts, and Gram-positive bacteria. The fast atom bombardment mass spectra revealed that the individual isolated antibiotics are still mixture of two homologous components, being very difficult to separate from each other.

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