ATPENINS, NEW ANTIFUNGAL ANTIBIOTICS PRODUCED BY PENICILLIUM SP. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

SATOSHI OMURA; HIROSHI TOMODA; KEIKO KIMURA; D.-Z. ZHENT; HIDETOSHI KUMAGAI; KAZUAKI IGARASHI; NOBUTAKA IMAMURA; YOKO TAKAHASHI; YOSHITAKE TANAKA; YUZURU IWAI

doi:10.7164/antibiotics.41.1769

ATPENINS, NEW ANTIFUNGAL ANTIBIOTICS PRODUCED BY PENICILLIUM SP.

PRODUCTION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

SATOSHI OMURA, HIROSHI TOMODA, KEIKO KIMURA, D.-Z. ZHENT, HIDETOSHI KUMAGAI, KAZUAKI IGARASHI, NOBUTAKA IMAMURA, YOKO TAKAHASHI, YOSHITAKE TANAKA, YUZURU IWAI

Author information

SATOSHI OMURA
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
HIROSHI TOMODA
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
KEIKO KIMURA
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
D.-Z. ZHENT
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
Present address: Shenyang College of Pharmacy
HIDETOSHI KUMAGAI
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
KAZUAKI IGARASHI
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
NOBUTAKA IMAMURA
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
YOKO TAKAHASHI
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
YOSHITAKE TANAKA
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University
YUZURU IWAI
The Kitasato Institute, and School of Pharmaceutical Sciences of Kitasato University

JOURNAL FREE ACCESS

1988 Volume 41 Issue 12 Pages 1769-1773

DOI https://doi.org/10.7164/antibiotics.41.1769

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Abstract

Penidllium sp. FO-125, a soil isolate, was found to produce a new antifungal antibiotic complex named atpenin. Three components A4, A5 and B were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and HPLC. The molecular formula of atpenins A4, A5 and B were determined to be C₁₅H₂₂NO₅Cl, C₁₅H₂₁NO₅Cl₂ and C₁₅H₂₃NO₅, respectively, on the basis of high resolution electron impact mass spectrometry and elemental analysis. They are active against filamentous fungi, especially, Trichophyton sp.

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