METABOLIC PRODUCTS OF MICROORGANISMS. 252 ISOLATION OF NEW NIKKOMYCINS FROM STREPTOMYCES TENDAE

HEINRICH DECKER; CHRISTIANS BORMANN; HANS-PETER FIEDLER; HANS ZÄHNER; HOLGER HEITSCH; WILFRIED A. KÖNIG

doi:10.7164/antibiotics.42.230

METABOLIC PRODUCTS OF MICROORGANISMS. 252 ISOLATION OF NEW NIKKOMYCINS FROM STREPTOMYCES TENDAE

HEINRICH DECKER, CHRISTIANS BORMANN, HANS-PETER FIEDLER, HANS ZÄHNER, HOLGER HEITSCH, WILFRIED A. KÖNIG

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JOURNAL FREE ACCESS

1989 Volume 42 Issue 2 Pages 230-235

DOI https://doi.org/10.7164/antibiotics.42.230

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Abstract

Two new nikkomycins were isolated from the culture broth of Streptomyces tendae Tü 901/PF 53⁺ -3. The new compounds are the dipeptide nikkomycin pseudo-Z (ψZ) and tripeptide nikkomycin pseudo-J (ψJ), which are analogues to nikkomycins Z and J. Nikkomycins pseudo-Z and pseudo-J have a C-glycosidic linkage between uracil and 5-amino-5-deoxy-D-allo-furanuronic acid, which is comparable to the C-glycosidic bond in pseudouridine. The new CC-nucleoside nikkomycins exhibit a lower biological activity than the CN-nucleoside nikkomycins.

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