The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SYNTHESIS AND ANTIBACTERIAL EVALUATION OF N-ALKYL VANCOMYCINS
R. NAGARAJAN, A. A. SCHABEL, J. L. OCCOLOWITZ, F. T. COUNTER, J. L. OTT, A. M. FELTY-DUCKWORTH
Author information
JOURNAL FREE ACCESS

1989 Volume 42 Issue 1 Pages 63-72

Details
Abstract

Over eighty N-alkyl vancomycins were synthesized by reductive alkylation of vancomycin with the appropriate aldehydes. The N-alkyl vancomycins exhibit greater antibacterial activity than the corresponding N-acyl vancomycins and the parent antibiotic. Some of these semisynthetic vancomycins are five times more active than vancomycin. The N-alkyl vancomycins also show longer elimination half-lives in rats than vancomycin.

Content from these authors
© Japan Antibiotics Research Association
Previous article Next article
Favorites & Alerts

Recently viewed articles
Predecessor

The Journal of Antibiotics, Series A

Share this page
feedback
 Top