EPONEMYCIN, A NEW ANTIBIOTIC ACTIVE AGAINST B16 MELANOMA I. PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

KOKO SUGAWARA; MASAMI HATORI; YUJI NISHIYAMA; KOJI TOMITA; HIDEO KAMEI; MASATAKA KONISHI; TOSHIKAZU OKI

doi:10.7164/antibiotics.43.8

EPONEMYCIN, A NEW ANTIBIOTIC ACTIVE AGAINST B16 MELANOMA

I. PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

KOKO SUGAWARA, MASAMI HATORI, YUJI NISHIYAMA, KOJI TOMITA, HIDEO KAMEI, MASATAKA KONISHI, TOSHIKAZU OKI

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 1 Pages 8-18

DOI https://doi.org/10.7164/antibiotics.43.8

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Abstract

Streptomyces hygroscopicus No. P247-71 (ATCC 53709) produced a novel antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1, 2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L-serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor antibiotics.

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