The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
NOVEL AVERMECTINS PRODUCED BY MUTATIONAL BIOSYNTHESIS
CHRISTOPHER J. DUTTONSTEPHEN P. GIBSONALEXANDER C. GOUDIEKELVIN S. HOLDOMMICHAEL S. PACEYJOHN C. RUDDOCKJOHN D. BU'LOCKMICHELLE K. RICHARDS
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1991 Volume 44 Issue 3 Pages 357-365

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Abstract

Avermectins with a wide range of novel C-25 substituents have been prepared by feeding carboxylic acids or their biosynthetic precursors to a Streptomyces avermitilis mutant strain ATCC 53568. This organism lacks the ability to form isobutyric and S-2-methylbutyric acids from their 2-oxo acid precursors and thus is unable to produce natural avermectins unless supplied with these acids. The novel avermectins produced by mutational biosynthesis possess broad-spectrum antiparasitic activity.

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© Japan Antibiotics Research Association
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