The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
PANNORIN, A NEW 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR PRODUCED BY Chrysosporium pannorum
HARUO OGAWAKEIJI HASUMIKAORU SAKAISHIGEO MURAKAWAAKIRA ENDO
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1991 Volume 44 Issue 7 Pages 762-767

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Abstract

Pannorin, a naphthopyrone that inhibits 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol synthesis, was isolated from a culture broth of Chrysosporium pannorum Ml0539 by solvent extraction, Bio-Gel P-6 column chromatography and reverse phase HPLC (Silica ODS). Spectroscopic analyses of the compound yielded 4, 8, 10-trihydroxy-5-methyl-2H-naphtho[1, 2-b]pyran-2-one as the proposed structure. Pannorin inhibited HMG-CoA reductase and in vitro sterol synthesis 50% at a concentration of 160μM.

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© Japan Antibiotics Research Association
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