The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
WS009 A AND B, NEW ENDOTHELIN RECEPTOR ANTAGONISTS ISOLATED FROM Streptomyces sp. No. 89009
I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES
SUSUMU MIYATA, NOBUTAKA OHHATA, HIDETUGU MURAI, YUKO MASUI, MASAMI EZAKI, SHIGEHIRO TAKASE, MOTOAKI NISHIKAWA, SUMIO KIYOTO, MASAKUNI OKUHARA, MASANOBU KOHSAKA
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1992 Volume 45 Issue 7 Pages 1029-1040

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Abstract

WS009 A and B novel endothelin receptor antagonists, have been isolated from the fermentation broth of Streptomyces sp. No. 89009. These antagonists were purified from the culture filtrate followed by Diaion SP-207, DEAE Toyopearl column chromatography and HPLC. WS009 A and B showed selective activity in an endothelin receptor binding assay with IC50 of 5.8 × 10-6M and 6.7 × 10-7M, respectively. On the basis of spectroscopic and chemical evidence, the structures of WS009 A and B have been established as 1 and 3, and are highly hydroxylated benz[a]anthraquinone chromophores.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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