The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
METABOLIC PRODUCTS OF MICROORGANISMS. 261 OBSCUROLIDES, A NOVEL CLASS OF PHOSPHODIESTERASE INHIBITORS FROM STREPTOMYCES
I. PRODUCTION, ISOLATION, STRUCTURAL ELUCIDATION AND BIOLOGICAL ACTIVITY OF OBSCUROLIDES A1 TO A4
HUBERT HOFF, HANNELORE DRAUTZ, HANS-PETER FIEDLER, HANS ZÄHNER, JOACHIM E. SCHULTZ, WALTER KELLER-SCHIERLEIN, SIEGRID PHILIPPS, MICHAEL RITZAU, AXEL ZEECK
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1992 Volume 45 Issue 7 Pages 1096-1107

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Abstract

A novel class of butyrolactones, named obscurolides, was isolated from the culture nitrate of Streptomyces viridochromogenes by chemical screening methods. The structural elucidation of the obscurolides A1 to A4 (1-4) is described. The carboxy group of the 4-aminobenzoic acid moiety of obscurolide A1 (1) is reduced in the other compounds. The isolated natural products have been proved to be diastereomeric mixtures by a partial racemization at C-7 which belongs to an allylic alcohol system. The obscurolides showed a weak inhibitory activity against calcium/calmodulindependent and independent phosphodiesterases from bovine.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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