TAUTOMERIC PHENOMENON OF A NOVEL POTENT IMMUNOSUPPRESSANT (FK506) IN SOLUTION I. ISOLATION AND STRUCTURE DETERMINATION OF TAUTOMERIC COMPOUNDS

Y. NAMIKI; N. KIHARA; S. KODA; K. HANE; T. YASUDA

doi:10.7164/antibiotics.46.1149

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

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Volume 46 (1993) Issue 7
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TAUTOMERIC PHENOMENON OF A NOVEL POTENT IMMUNOSUPPRESSANT (FK506) IN SOLUTION

I. ISOLATION AND STRUCTURE DETERMINATION OF TAUTOMERIC COMPOUNDS

Y. NAMIKI, N. KIHARA, S. KODA, K. HANE, T. YASUDA

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 7 Pages 1149-1155

DOI https://doi.org/10.7164/antibiotics.46.1149

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Abstract

Tautomeric phenomenon was observed in the HPLC chromatogram obtained from a novel potent immunosuppressant, FK506, in ethanol solution. Two tautomeric compounds derived from FK506 were isolated and purified by HPLC. Their structures were elucidated by spectral analyses. The mechanisms for this tautomerization were also established based on the results of structure analysis.

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