STRUCTURES OF ENZYMATICALLY MODIFIED PRODUCTS OF ARBEKACIN BY METHICILLIN-RESISTANT Staphylococcus aureus

SHINICHI KONDO; ATSUSHI TAMURA; SHUICHI GOMI; YOKO IKEDA; TOMIO TAKEUCHI; SUSUMU MITSUHASHI

doi:10.7164/antibiotics.46.310

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

STRUCTURES OF ENZYMATICALLY MODIFIED PRODUCTS OF ARBEKACIN BY METHICILLIN-RESISTANT Staphylococcus aureus

SHINICHI KONDO, ATSUSHI TAMURA, SHUICHI GOMI, YOKO IKEDA, TOMIO TAKEUCHI, SUSUMU MITSUHASHI

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 2 Pages 310-315

DOI https://doi.org/10.7164/antibiotics.46.310

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Abstract

Only a limited number of strains of methicillin-resistant Staphylococcus aureus (MRSA) moderately resistant to arbekacin (ABK) have been isolated clinically. Three inactivated products of ABK have been obtained by reaction with excess amounts of a crude enzyme preparation extracted from an ABK-resistant MRSA strain (MIC, 25μg/ml). The 2''-O-phosphate was the major product together with small amounts of the 6'-N-acetate and the double modification product. The structures of these modification products were determined by MS and NMR spectral analyses.

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