The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
FR901228, A NOVEL ANTITUMOR BICYCLIC DEPSIPEPTIDE PRODUCED BY Chromobacterium violaceum No. 968
I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES, AND ANTITUMOR ACTIVITY
HIROTSUGU UEDAHIDENORI NAKAJIMAYASUHIRO HORITAKASHI FUJITAMAKOTO NISHIMURATOSHIO GOTOMASAKUNI OKUHARA
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1994 Volume 47 Issue 3 Pages 301-310

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Abstract

A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as colorless prisms and the molecular formula was determined as C24H36N4O6S2. This antibiotic reverted the transformed morphology of a Ha-ras transformant to normal, and exhibited prominent antitumor activities against murine and human tumor cell lines both in vitro and in vivo.

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© Japan Antibiotics Research Association
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