NOVEL ASPARTYL PROTEASE INHIBITORS, YF-0200R-A and B

TSUTOMU SATO; KOJI NAGAI; MITSUYOSHI SHIBAZAKI; KENJI ABE; YUKIHIRO TAKEBAYASHI; BUD LUMANAU; RATNA MURNI RANTIATMODJO

doi:10.7164/antibiotics.47.566

TSUTOMU SATO, KOJI NAGAI, MITSUYOSHI SHIBAZAKI, KENJI ABE, YUKIHIRO TAKEBAYASHI, BUD LUMANAU, RATNA MURNI RANTIATMODJO

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JOURNAL FREE ACCESS

1994 Volume 47 Issue 5 Pages 566-570

DOI https://doi.org/10.7164/antibiotics.47.566

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Abstract

Novel pepstatin A-sensitive Candida albicans aspartyl protease inhibitors, named YF-0200R-A and B, were isolated by column chromatography and preparative HPLC from the fermentation broth of Streptomyces sp. YF-0200R. The structures of YF-0200R-A and B were elucidated by spectroscopic analysis as α, β and γ, δ unsaturated fatty acids with two or three hydroxyl groups. YF-0200R-A and B inhibit aspartyl protease from Candida albicans with IC₅₀ values of 6.5×10^-4M and 6.2×10^-4M, respectively.

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