The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Helioferins; Novel Antifungal Lipopeptides From Mycogone rosea: Screening, Isolation, Structures and Biological Properties
U. GRÄFEW. IHNM. RITZAUW. SCHADEC. STENGELB. SCHLEGELW. F. FLECKW. KÜNKELA. HÄRTLW. GUTSCHE
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1995 Volume 48 Issue 2 Pages 126-133

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Abstract

Helioferins A and B were detected as novel aminolipopeptides in cultures of Mycogone rosea DSM 8822 in the course of a screening for mediators of helianthate anion transfer from aqueous to toluene phases. Their structures as novel antibiotics and cytotoxic agents were elucidated by mass spectrometry and NMR spectroscopic methods. Antimicrobial activity was estimated against Candida albicans and Gram-positive bacteria including Mycobacterium spp.

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© Japan Antibiotics Research Association
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