The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Stachybocins, Novel Endothelin Receptor Antagonists, Produced by Stachybotrys sp. M6222
I. Taxonomy, Fermentation, Isolation and Characterization
MASATO NAKAMURA, YASUNOBU ITO, KIYOSHI OGAWA, YUJI MICHISUJI, SHIN-ICHI SATO, MASAKI TAKADA, MITSUO HAYASHI, SATOSHI YAGINUMA, SYUJI YAMAMOTO
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1995 Volume 48 Issue 12 Pages 1389-1395

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Abstract

Stachybocins A, B and C, novel endothelih (ET) receptor antagonists, were isolated from the culture filtrate of Stachybotrys sp. M6222. They were extracted with ethyl acetate and then purified by alumina and silica gel column chromatographies. The molecular formulae of Stachybocins were determined to be C52H70N2O10 (stachybocin A) and C52H70N2O11 (stachybocins B and C). It was supposed that they consisted of spirobenzofuran and terpene units from NMR spectra. They showed the inhibitory activity of 125I-ET-1 binding to rat ETA, human ETA and human ETB receptors.

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