Rifampicin Inactivation by Bacillus species

ERIC R. DABBS; KATSUKIYO YAZAWA; YASUSHI TANAKA; YUZURU MIKAMI; MAKOTO MIYAJI; SUSAN J. ANDERSEN; NAOKO MORISAKI; SHIGEO IWASAKI; OSAMU SHIDA; HIROAKI TAKAGI; KIYOSHI KADOWAKI

doi:10.7164/antibiotics.48.815

Rifampicin Inactivation by Bacillus species

ERIC R. DABBS, KATSUKIYO YAZAWA, YASUSHI TANAKA, YUZURU MIKAMI, MAKOTO MIYAJI, SUSAN J. ANDERSEN, NAOKO MORISAKI, SHIGEO IWASAKI, OSAMU SHIDA, HIROAKI TAKAGI, KIYOSHI KADOWAKI

Author information

ERIC R. DABBS
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
Permanent address: Genetics Department, University of the Witwatersrand
KATSUKIYO YAZAWA
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
YASUSHI TANAKA
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
YUZURU MIKAMI
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
MAKOTO MIYAJI
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
SUSAN J. ANDERSEN
Genetics Department, University of the Witwatersrand
NAOKO MORISAKI
Institute of Molecular and Cellular Bioscience, The University of Tokyo
SHIGEO IWASAKI
Institute of Molecular and Cellular Bioscience, The University of Tokyo
OSAMU SHIDA
Research Laboratory, Higeta Shoyu Co., Ltd.
HIROAKI TAKAGI
Research Laboratory, Higeta Shoyu Co., Ltd.
KIYOSHI KADOWAKI
Research Laboratory, Higeta Shoyu Co., Ltd.

JOURNAL FREE ACCESS

1995 Volume 48 Issue 8 Pages 815-819

DOI https://doi.org/10.7164/antibiotics.48.815

Details

Abstract

The ability of strains of Bacillus, Staphylococcus, Pseudomonas, and Escherichia coli to inactivate rifampicin was tested. Most Bacillus strains were found to inactivate rifampicin. Two modes of inactivation were identified; one was phosphorylation and the other involved decolorization. Presence or absence of either mechanism appeared unrelated to the phylogenetic relatedness of strains. None of the other organisms could inactivate this antibiotic.

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