Stachybotrin C and Parvisporin, Novel Neuritogenic Compounds I. Taxonomy, Isolation, Physico-chemical and Biological Properties

YURIKO NOZAWA; KYOKO YAMAMOTO; MAYUMI ITO; NORIYOSHI SAKAI; KAZUTOSHI MIZOUE; FUMIO MIZOBE; KAZUNORI HANADA

doi:10.7164/antibiotics.50.635

Stachybotrin C and Parvisporin, Novel Neuritogenic Compounds

I. Taxonomy, Isolation, Physico-chemical and Biological Properties

YURIKO NOZAWA, KYOKO YAMAMOTO, MAYUMI ITO, NORIYOSHI SAKAI, KAZUTOSHI MIZOUE, FUMIO MIZOBE, KAZUNORI HANADA

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JOURNAL FREE ACCESS

1997 Volume 50 Issue 8 Pages 635-640

DOI https://doi.org/10.7164/antibiotics.50.635

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Abstract

Stachybotrin C and parvisporin, novel neuritogenic compounds, were isolated from the culture broth of Stachybotrys parvispora F4708. Stachybotrin C induced significant neurite outgrowth in PC12 cells and showed cell survival activity in the primary culture of cerebral cortical neurons. Parvisporin demonstrated only weak neuritogenic activity.

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