New Anticancer Antibiotics Pelagiomicins, Produced by a New Marine Bacterium Pelagiobacter variabilis

NOBUTAKA IMAMURA; MIYUKI NISHIJIMA; TAKAHIDE TAKADERA; KYOKO ADACHI; MIHO SAKAI; HIROSHI SANO

doi:10.7164/antibiotics.50.8

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

New Anticancer Antibiotics Pelagiomicins, Produced by a New Marine Bacterium Pelagiobacter variabilis

NOBUTAKA IMAMURA, MIYUKI NISHIJIMA, TAKAHIDE TAKADERA, KYOKO ADACHI, MIHO SAKAI, HIROSHI SANO

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JOURNAL FREE ACCESS

1997 Volume 50 Issue 1 Pages 8-12

DOI https://doi.org/10.7164/antibiotics.50.8

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Abstract

In the course of our screening for new anticancer compounds produced by marine bacteria, we found that a new genus marine bacterium Pelagiobacter variabilis produced new phenazine antibiotics, pelagiomicins A, B and C. Those compounds were labile in water and alcohols. The absolute structure of the main component; pelagiomicin A, and the structures of the minor ones were determined from the spectroscopic data and by synthesis. Pelagiomicin A exhibits activity against Gram-positive and -negative bacteria and antitumor activity in vitro and in vivo.

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