The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
TMC-66, a New Endothelin Converting Enzyme Inhibitor Produced by Streptomyces sp. A5008
YASUYUKI ASAI, NOBUAKI NONAKA, SHIN-ICHI SUZUKI, MAKI NISHIO, KOHEI TAKAHASHI, HIDEAKI SHIMA, KENJI OHMORI, TETSUO OHNUKI, SABURO KOMATSUBARA
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1999 Volume 52 Issue 7 Pages 607-612

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Abstract

A new endothelin converting enzyme (ECE) inhibitor, TMC-66 was isolated from the fermentation broth of Streptomyces sp. A5008. The structure of TMC-66 was elucidated by spectroscopic analyses to be a new member of benzo[a]naphthacenequinone class of antibiotics. TMC-66 had a highly selective inhibitory activity for ECE with an IC50 value of 2.9μM. Taxonomy of the producing strain is also described.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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