Nafuredin, a Novel Inhibitor of NADH-fumarate Reductase, Produced by Aspergillus niger FT-0554

HIDEAKI UI; KAZURO SHIOMI; YUUICHI YAMAGUCHI; ROKURO MASUMA; TOHRU NAGAMITSU; DAISUKE TAKANO; TOSHIAKI SUNAZUKA; MICHIO NAMIKOSHI; SATOSHI OMURA

doi:10.7164/antibiotics.54.234

Nafuredin, a Novel Inhibitor of NADH-fumarate Reductase, Produced by Aspergillus niger FT-0554

HIDEAKI UI, KAZURO SHIOMI, YUUICHI YAMAGUCHI, ROKURO MASUMA, TOHRU NAGAMITSU, DAISUKE TAKANO, TOSHIAKI SUNAZUKA, MICHIO NAMIKOSHI, SATOSHI OMURA

Author information

HIDEAKI UI
Research Center for Biological Function, The Kitasato Institute
KAZURO SHIOMI
Research Center for Biological Function, The Kitasato Institute
YUUICHI YAMAGUCHI
Research Center for Biological Function, The Kitasato Institute
ROKURO MASUMA
Research Center for Biological Function, The Kitasato Institute
TOHRU NAGAMITSU
Research Center for Biological Function, The Kitasato Institute
DAISUKE TAKANO
School of Pharmaceutical Sciences, Kitasato University
TOSHIAKI SUNAZUKA
School of Pharmaceutical Sciences, Kitasato University
MICHIO NAMIKOSHI
Department of Ocean Sciences, Tokyo University of Fisheries
SATOSHI OMURA
Research Center for Biological Function, The Kitasato Institute

JOURNAL FREE ACCESS

2001 Volume 54 Issue 3 Pages 234-238

DOI https://doi.org/10.7164/antibiotics.54.234

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Abstract

A novel compound, nafuredin, was isolated as an inhibitor of anaerobic electron transport (NADH-fumarate reductase). It was obtained from culture broth of Aspergillus niger FT-0554 isolated from a marine sponge. The structure was elucidated as an epoxy-δ-lactone with an attached methylated olefinic side chain on the basis of spectral analysis.

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