S-15183a and b, New Sphingosine Kinase Inhibitors, Produced by a Fungus

KEITA KONO; MASAHIRO TANAKA; YASUNORI ONO; TSUYOSHI HOSOYA; TAKESHI OGITA; TAKAFUMI KOHAMA

doi:10.7164/antibiotics.54.415

KEITA KONO, MASAHIRO TANAKA, YASUNORI ONO, TSUYOSHI HOSOYA, TAKESHI OGITA, TAKAFUMI KOHAMA

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JOURNAL FREE ACCESS

2001 Volume 54 Issue 5 Pages 415-420

DOI https://doi.org/10.7164/antibiotics.54.415

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Abstract

In the course of our screening for inhibitors of sphingosine kinase, we found two active compounds in a culture broth of a fungus, Zopfiella inermis SANK 15183. The structures of the compounds, named S-15183a and b, were elucidated by a combination of spectroscopic analyses to be new azaphilone-type metabolites. S-15183a and b inhibited sphingosine kinase from rat liver with IC₅₀ values of 2.5 and 1.6μM, respectively. S-15183a also inhibited endogenous SPH kinase activity in intact platelets.

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