TMC-69, a New Antitumor Antibiotic with Cdc25A Inhibitory Activity, Produced by Chrysosporium sp. TCI068 Taxonomy, Fermentation and Biological Activities

NAOMITSU HIRANO; JUN KOHNO; SHIHO TSUNODA; MAKI NISHIO; NOBORU KISHI; TORU OKUDA; KIMIO KAWANO; SABURO KOMATSUBARA; NORIYUKI NAKANISHI

doi:10.7164/antibiotics.54.421

TMC-69, a New Antitumor Antibiotic with Cdc25A Inhibitory Activity, Produced by Chrysosporium sp. TCI068

Taxonomy, Fermentation and Biological Activities

NAOMITSU HIRANO, JUN KOHNO, SHIHO TSUNODA, MAKI NISHIO, NOBORU KISHI, TORU OKUDA, KIMIO KAWANO, SABURO KOMATSUBARA, NORIYUKI NAKANISHI

Author information

NAOMITSU HIRANO
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
JUN KOHNO
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
SHIHO TSUNODA
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
MAKI NISHIO
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
NOBORU KISHI
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
TORU OKUDA
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
Present address: Applied Life Science Research Center, Tamagawa University Research Institute
KIMIO KAWANO
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
SABURO KOMATSUBARA
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
NORIYUKI NAKANISHI
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.

JOURNAL FREE ACCESS

2001 Volume 54 Issue 5 Pages 421-427

DOI https://doi.org/10.7164/antibiotics.54.421

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Abstract

A new antibiotic designated TMC-69 has been isolated from, the fermentation broth of a fungal strain Chrysosporium sp. TC 1068. TMC-69 exhibited moderate in vitro cytotoxic activity. TMC-69-6H, a derivative of TMC-69 prepared by hydrogenation, possessed more potent in vitro cytotoxicity than TMC-69, and exhibited in vivo antitumor activity against murine P388 leukemia and B16 melanoma. TMC-69-6H was found to specifically inhibit Cdc25A and B phosphatases.

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