Endophenazines A-D, New Phenazine Antibiotics from the Arthropod Associated Endosymbiont Streptomyces anulatus I. Taxonomy, Fermentation, Isolation and Biological Activities

KLAUS GEBHARDT; JUDITH SCHIMANA; PHILIPP KRASTEL; KONRAD DETTNER; JOACHIM RHEINHEIMER; AXEL ZEECK; HANS-PETER FIEDLER

doi:10.7164/antibiotics.55.794

Endophenazines A-D, New Phenazine Antibiotics from the Arthropod Associated Endosymbiont Streptomyces anulatus

I. Taxonomy, Fermentation, Isolation and Biological Activities

KLAUS GEBHARDT, JUDITH SCHIMANA, PHILIPP KRASTEL, KONRAD DETTNER, JOACHIM RHEINHEIMER, AXEL ZEECK, HANS-PETER FIEDLER

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JOURNAL FREE ACCESS

2002 Volume 55 Issue 9 Pages 794-800

DOI https://doi.org/10.7164/antibiotics.55.794

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Abstract

Four new members of the phenazine family, endophenazines A-D, and the already known phenazine-1-carboxylic acid (tubermycin B) were detected in the culture broth of various endosymbiotic Streptomyces anulatus strains by chemical screening in a combination of TLC-staining reagents and HPLC-diode array analysis. The endosymbiotic strains were isolated from four different arthropod hosts at various sites. The new phenazine compounds showed antimicrobial activities against Gram-positive bacteria and some filamentous fungi, and herbicidal activity against Lemna minor (duckweed).

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