2002 Volume 55 Issue 11 Pages 993-1003
Chemical derivation methods to prepare 26-acyloxy and 26-hydroxymilbemycins, which had been reported as natural products, milbemycins α9, α10, α11, α12, α14, α15, α20, α21, α22, α23, α26, α27 from milbemycins A3, A4 were reported. Δ2, 3, Δ4, 26-Milbemycins A3, A4, which had also been reported as natural products, were further prepared from milbemycins A3, A4. Their acaricidal activities were also assessed against the organophosphorus-sensitive two-spotted spider mite (Tetranychus urticae) on primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.