The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Pyrocoll, an Antibiotic, Antiparasitic and Antitumor Compound Produced by a Novel Alkaliphilic Streptomyces Strain
ANKE DIETERANDREAS HAMMHANS-PETER FIEDLERMICHAEL GOODFELLOWWERNER E. G. MÜLLERRETO BRUNWINFRIED BEILGERHARD BRINGMANN
Author information
JOURNAL FREE ACCESS

2003 Volume 56 Issue 7 Pages 639-646

Details
Abstract

A new secondary metabolite was detected in the culture extract of Streptomyces sp. AK 409 by HPLC-diode-array screening. The metabolite was identified as pyrocoll, which is known to be a constituent of cigarette smoke. Pyrocoll is known as a synthetic compound, but until now had not been isolated as a natural product from a microorganism. The compound showed biological activity against various Arthrobacter strains, filamentous fungi, several pathogenic protozoa, and some human tumor cell lines.

Content from these authors
© Japan Antibiotics Research Association
Previous article Next article
feedback
Top